Borrelia miyamotoi

Human infection with Borrelia miyamotoi may cause symptomatic illness.  Several cases have been identified in Wisconsin residents (Jobe et al. 2016) including at least one human case identified in a non-traveler as of 2017.

This bacterium is different from Borrelia burgdorferi and Borrelia mayonii which cause Lyme Disease.  Borrelia miyamotoi is one of several species that cause a relapsing fever type of illness.  Borrelia miyamatoi is found in blacklegged (deer) ticks and transmitted by tick bite.  Larvae, nymphs and adults of the blacklegged tick may all be infected because this pathogen is transmitted from adult females to their eggs and subsequent offspring (larvae). In Wisconsin, studies have found that 0-8% of the nymphs of Ixodes scapularis may be infected with Borrelia miyamotoi (Barbour et al. 2009).  Research suggests that the adults will have similar rates of infection.

A recent report (Gugliotta et al. 2013) in the New England Journal of Medicine, identified a patient with meningoencephalitis as a probable result of infection with Borrelia miyamotoi.  A second report (Krause et al 2013) in the same journal also identified several patients with symptoms and serology that indicated infection causing illness had occurred. “The most common clinical manifestations of B. miyamotoi infection are fever, fatigue,. miyamotoi infecti headache, chills, myalgia, arthralgia, and nausea. Symptoms generally resolve within a week of the start of antibiotic therapy. B. miyamotoi infection should be considered in patients with acute febrile illness who have been exposed to Ixodes ticks in a region where Lyme disease occurs.” (Krause et al. 2015)

References cited

Barbour A. et al. 2009. Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species. American Journal of Tropical Medicine and Hygiene 81:1120-1131.

Gugliotta J et al. 2013.  Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient.  New England Journal of Medicine 368:240-245.

Jobe D. et al. “Borrelia miyamotoi Infection in Patients from Upper Midwestern United States, 2014–2015.” Emerging Infectious Diseases 22.8 (2016): 1471–1473.

Krause PJ. et al.  2013.  Human Borrelia miyamotoi infection in the United States.  New England Journal of Medicine 368:291-293.

Krause, Peter J., et al. Borrelia miyamotoi infection in nature and in humans. Clinical Microbiology and Infection 21.7 (2015): 631-639.